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MABT363 Anti-Meprin A subunit beta Antibody, clone 10F4.1

Anti-Meprin A subunit beta Antibody, clone 10F4.1 is an antibody against Meprin A subunit beta for use in Western Blotting, Immunohistochemistry.

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Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: MEP1B UniProt Number: Q16820
MABT363
100 μg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT363
      DescriptionAnti-Meprin A subunit beta Antibody, clone 10F4.1
      Alternate Names
      • Meprin A subunit beta
      • Endopeptidase-2
      • Meprin B
      • N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta
      • PABA peptide hydrolase
      • PPH beta
      Background InformationMeprin A subunit beta (EC 3.4.24.63; UniProt Q16820; also known as Endopeptidase-2, Meprin B, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta, PABA peptide hydrolase, PPH beta) is encoded by the MEP1B gene (Gene ID 4225) in human. Meprins are multi-domain zinc-containing proteinases that are members of the astacin family and metzincin superfamily of metalloproteinases. Meprins are expressed in epithelial cells in the kidney and intestine, as well as in skin, leukocytes, and lung. The meprin α and β subunits differ in their substrate specificities. Meprin α has a preference for small or hydrophobic residues flanking the cleavage site, whereas meprin β has a preference for negatively charged residues. Both subunits are synthesized as type 1 membrane spanning proteins, however, the transmembrane and cytoplasmic portion of meprin α, but not β, is proteolytically cleaved off in the endoplasmic reticulum. The meprin subunits form disulfide-linked homo- and heterodimers. Meprin β dimers (called meprin B) and meprin α/β dimers (heteromeric meprin A) are membrane-bound proteins, whereas meprin α homodimers are secreted and tend to self-associate into larger oligomers of over 10 subunits.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Meprin A subunit beta Antibody, clone 10F4.1 is an antibody against Meprin A subunit beta for use in Western Blotting, Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected Meprin A subunit beta in human small intestine, rat small intestine, and human cerebral cortex tissue.
      Biological Information
      ImmunogenGST-tagged recombinant fragment from the metalloprotease domain of human Meprin A subunit beta.
      EpitopeMetalloprotease domain.
      Clone10F4.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MEP1B
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~80 kDa observed. 79.6 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human small intestine tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Meprin A subunit beta in 10 µg of human small intestine tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABT363 04055977314304