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AB5666P Anti-Neurite Outgrowth Inhibitor A/B/C Antibody

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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Catalogue NumberAB5666P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Neurite Outgrowth Inhibitor A/B/C Antibody
      Alternate Names
      • Nogo-A/B/C
      Product Information
      FormatAffinity Purified
      PresentationLiquid in PBS containing 0.1% BSA and 0.05% sodium azide.
      Quality LevelMQ100
      ApplicationAnti-Neurite Outgrowth Inhibitor A/B/C Antibody is an antibody against Neurite Outgrowth Inhibitor A/B/C for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL. The calculated molecular weight of Nogo-A is approximately 135 kDa. However a molecular weight of approximately 180 kDa has been reported for full length Nogo-A (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).

      ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 13 amino acid peptide between the putative 2nd-3rd transmembrane domain of human Nogo-A (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes human Neurite Outgrowth Inhibitor Protein A/B/C (Nogo-A/B/C). The immunogen peptide is within the 25 amino acid region identified for the inhibition of neurite outgrowth (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).The immunogen shows no significant sequence homology with other known proteins.

      SPECIES REACTIVITIES: The immunogen peptide is 92% conserved in rat Nogo or rat foocen-m1.2 protein (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998). Reactivity with other species has not been confirmed.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
      Gene Symbol
      • RTN4
      • RTN4-B1
      • Nbla10545
      • RTN-X
      • reticulon-4A
      • Nogo-C
      • NSP
      • RTN-x
      • ASY
      • foocen
      • NSP-CL
      • NOGOC
      • RTN4-A
      • Reticulon-4
      • Nbla00271
      • KIAA0886
      • NOGOA
      • Reticulon-5
      • Foocen
      • NI220/250
      • RTN4-C
      • RTN4-B2
      • SP1507
      • NOGO-A
      • NOGO
      • NOGOB
      • Nogo-B
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NQC3 # Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
      SIZE: 1192 amino acids; 129931 Da
      SUBUNIT: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2.
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
      TISSUE SPECIFICITY: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis- specific.
      DOMAIN: SwissProt: Q9NQC3 Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo- 66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
      SIMILARITY: Contains 1 reticulon domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Global Trade Item Number
      Référence GTIN
      AB5666P 04053252275326


      Anti-Neurite Outgrowth Inhibitor A/B/C Antibody Certificats d'analyse

      TitreNuméro de lot

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Nogo-B is associated with cytoskeletal structures in human monocyte-derived macrophages.
      Schanda, K; Hermann, M; Stefanova, N; Gredler, V; Bandtlow, C; Reindl, M
      BMC research notes  4  6  2010

      Afficher le résumé Article en texte intégral
      21235733 21235733

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