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182540 Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem

The Aromatase Inhibitor I, also referenced under CAS 331684-05-0, controls the biological activity of Aromatase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone

Primary Target: P450 arom.
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182540
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
331684-05-0C₁₇H₁₁N₃O₄

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182540-1MG
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      		 Ampoule plast. 1 mg
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      Description
      OverviewA potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC50 = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.
      Catalogue Number182540
      Brand Family Calbiochem®
      Synonyms4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
      References
      ReferencesRecanatini, M., et al. 2001. J. Med. Chem. 44, 672.
      Product Information
      CAS number331684-05-0
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₇H₁₁N₃O₄
      Chemical formulaC₁₇H₁₁N₃O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP450 arom.
      Primary Target IC<sub>50</sub>40 nM against P450arom
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      182540-1MG 04055977205091

      Documentation

      Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      182540

      Références bibliographiques

      Aperçu de la référence bibliographique
      Recanatini, M., et al. 2001. J. Med. Chem. 44, 672.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
      DescriptionA potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC50 = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331684-05-0
      Chemical formulaC₁₇H₁₁N₃O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRecanatini, M., et al. 2001. J. Med. Chem. 44, 672.