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203646 BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem

203646
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Empirical FormulaCAS #
C₂₄H₂₀N₄O 1206711-16-1

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203646-5MG
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      Description
      OverviewA cell-permeable, potent, and highly selective BMPR inhibitior (IC50 against human ALK2/BMPR-I = 107.9 nM), exhibiting no activity toward ALK5, ALK6, AMPK, FLK1/KDR/VEGRF2, or PDGFRβ. Comparing to its non-BMPR-selective structural analog dorsomorphin (Cat. Nos. 171260 & 171261), DMH1 is 12.5-times more potent in preventing BMP pathway-dependent dorsoventral development (EC100 = 0.2 µM) in zebrafish embryo in vivo, while being non-toxic to the fish embryo and exhibiting no effect against VEGF signaling-dependent intersomitic vessel formation even at concentrations as high as 50 µM.
      Catalogue Number203646
      Brand Family Calbiochem®
      SynonymsALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
      References
      ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
      Product Information
      CAS number1206711-16-1
      FormOrange solid
      Hill FormulaC₂₄H₂₀N₄O
      Chemical formulaC₂₄H₂₀N₄O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      203646

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-March-2012 JSW
      SynonymsALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
      DescriptionA cell-permeable, potent, and highly selective BMPR (bone morphogenetic protein receptor) inhibitior (IC50 against human ALK2/BMPR-I = 107.9 nM) that exhibits no inhibitory activity against ALK5, AMPK, FLK1/KDR/VEGRF2, or PDGFRβ. Effectively blocks ALK2- and ALK3-, but not ALK6-, mediated transcription activity (IC50 <500 nM, <100 nM, and >10 µM in reporter assays using C2C12BRA expressing constitutively active ALK2, ALK3, or ALK6, respectively). Comparing to its non-BMPR-selective structural analog dorsomorphin (DM; Cat. Nos. 171260 & 171261), DMH1 is 12.5-times more potent in preventing BMP pathway-dependent DV (dorsoventral) development (EC100 = 0.2 µM DMH1 or 2.5 µM DM) in zebrafish embryo in vivo, while being non-toxic to the fish embryo and exhibiting no effect against VEGF signaling-dependent intersomitic vessel (ISV) formation even at concentrations as high as 50 µM.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1206711-16-1
      Chemical formulaC₂₄H₂₀N₄O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (16.6 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.