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197331 Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem

197331
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Empirical FormulaCAS #
C₂₄H₂₁N₃O₆S₂ 810659-53-1

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197331-5MG
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      Flacon en verre 5 mg
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      Description
      OverviewA cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-xL-dependent cells, even at a concentration of 5 µM. Preferentially binds Bcl-2 (Ki = 1.3 µM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochrome c from mitochondria and activate caspase-9.
      Catalogue Number197331
      Brand Family Calbiochem®
      Synonyms2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester
      References
      ReferencesReal, P.J., et al. 2004. Cancer Res. 64, 7947.
      Product Information
      CAS number810659-53-1
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₂₄H₂₁N₃O₆S₂
      Chemical formulaC₂₄H₂₁N₃O₆S₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBcl-2
      Primary Target K<sub>i</sub>1.3 µM in binding Bcl-2
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      197331

      Références bibliographiques

      Aperçu de la référence bibliographique
      Real, P.J., et al. 2004. Cancer Res. 64, 7947.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      Synonyms2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester
      DescriptionA cell-permeable molecule that targets the BH3•domain interaction and selectively induces apoptosis in Bcl-2-overexpressing cells (<300 nM in MDA-MB435B breast cancer cells). Exhibits little effect on a variety of primary cells and Bcl-xL-dependent cells, even at a concentrations as high as 5 µM. Inhibits the binding of Bid BH3 to Bcl-2 thereby blocking the anti-apoptotic activity of Bcl-2.
      FormRed solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number810659-53-1
      Chemical formulaC₂₄H₂₁N₃O₆S₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesReal, P.J., et al. 2004. Cancer Res. 64, 7947.