Millipore Sigma Vibrant Logo

SCT246 BioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe

BioCyTASQ detects ribosomal RNA associated with perinuclear rough ER regions. BioCyTASQ is suitable for G4 capture pull-down assays as well as cellular imaging.2 BioCyTASQ G4 probe is not recommended for live-cell imaging applications. The biotinylated BioTracker BioCyTASQ G-quadruplex G4 cell probe makes is a powerful tool for biochemical and cellular analysis of G4 by fluorescent detection when used with a fluorescent streptavidin.

View Products on Sigmaaldrich.com
SCT246
1 mg  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

       

      Contacter le Service Clients

      Aperçu

      Replacement Information
      Description
      Catalogue NumberSCT246
      DescriptionBioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe
      Alternate Names
      • G4 probe
      • G quadruplex probe
      • Live Cell Imaging Probe
      • G4 ligand
      • G4 tetrad probe
      Background InformationDNA/RNA G-quadruplexes (G4s) are four-stranded nucleic acid structures that fold from numerous guanine (G)-rich sequences found in the genome and transcriptome. Their abundance and localization in critical regulatory regions make them key players in genetic diseases (cancer, neuropathology), but not only (e.g., viral infection). For this reason G4s have garnered intense interest as potential targets in different therapeutic areas.

      The BioTracker™ BioCyTASQ G-quadruplex G4 cell probe is optimized for detection (1) and/or the isolation of G4s (2,3). BioCyTASQ utilizes the template-assembled synthetic G-quartets (TASQ) (4) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.

      References
      1. ACS Chem Biol. 2021, 16: 905–914
      2. Nature Protoc. 2022, 17: 870–889
      3. STAR Protoc. 2024, 5: 103480
      4. Acc. Chem. Res. 2023, 56: 350–362
      5. iScience 2023, 26:106846
      References
      Product Information
      Detection methodFluorescence
      FormatLyophilized solid
      PresentationLyophilized. White solid.
      Quality LevelMQ100
      Applications
      ApplicationBioCyTASQ detects ribosomal RNA associated with perinuclear rough ER regions. BioCyTASQ is suitable for G4 capture pull-down assays as well as cellular imaging.2 BioCyTASQ G4 probe is not recommended for live-cell imaging applications. The biotinylated BioTracker BioCyTASQ G-quadruplex G4 cell probe makes is a powerful tool for biochemical and cellular analysis of G4 by fluorescent detection when used with a fluorescent streptavidin.
      Key Applications
      • RNA Detection
      • DNA-binding Proteins
      • Nucleic Acid Purification and Concentration
      Application NotesFluorescent detection of nucleic acid G4 quadruplexes in cells and tissues
      Biological Information
      Molecular Weight968 g/mol
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker™ BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      SCT246 04065268798782