203734 Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem

203734
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Empirical FormulaCAS #
C₅₀H₇₂O₁₄ 85079-48-7

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      Description
      OverviewLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
      Catalogue Number203734
      Brand Family Calbiochem®
      SynonymsPumiliotoxin, Dihydrobrevetoxin B
      References
      ReferencesBaden, D.G., et al. 1994. Nat. Toxins 2, 212.
      Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
      Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
      Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
      Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
      Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
      Baden, D.G., et al. 1988. Toxicon 26, 97.
      Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
      Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
      Baden, D.G., et al. 1982. Toxicon 19, 455.
      Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
      Product Information
      CAS number85079-48-7
      ATP CompetitiveN
      FormSolid
      Hill FormulaC₅₀H₇₂O₁₄
      Chemical formulaC₅₀H₇₂O₁₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationBrevetoxin PbTx-3, Ptychodiscus brevis, CAS 85079-48-7, is a lipid-soluble polyether marine toxin that acts as a voltage-dependent Na+ channel activator. Causes contractile paralysis in animal models.
      Biological Information
      Primary TargetVoltage-dependent Na+ channel activator
      Purity>95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXW5885000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
      End use certificateY
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      203734

      Références bibliographiques

      Aperçu de la référence bibliographique
      Baden, D.G., et al. 1994. Nat. Toxins 2, 212.
      Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
      Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
      Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
      Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
      Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
      Baden, D.G., et al. 1988. Toxicon 26, 97.
      Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
      Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
      Baden, D.G., et al. 1982. Toxicon 19, 455.
      Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2010 JSW
      SynonymsPumiliotoxin, Dihydrobrevetoxin B
      DescriptionLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number85079-48-7
      RTECSXW5885000
      Chemical formulaC₅₀H₇₂O₁₄
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (30 mg/ml), Methanol (30 mg/ml), Acetonitrile(30 mg/ml), Chloroform (30 mg/ml), Ethanol (10 mg/ml). Only sparingly soluble in H₂O
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
      Toxicity Highly Toxic
      ReferencesBaden, D.G., et al. 1994. Nat. Toxins 2, 212.
      Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
      Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
      Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
      Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
      Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
      Baden, D.G., et al. 1988. Toxicon 26, 97.
      Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
      Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
      Baden, D.G., et al. 1982. Toxicon 19, 455.
      Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

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      Catégories

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