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Description
Overview
Zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Non-denaturing zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than the structurally related carboxylic acid anions, and is more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding to opiates. Also capable of disaggregating P 450 to its monomeric form without denaturation. Has a small micellar molecular weight (6150 Daltons) and a high critical micellar concentration (6-10 mM). Can be removed from either gels or protein solutions by dialysis. Aggregation number: 4-14.
Form
White crystalline powder
CAS number
75621-03-3
Chemical formula
C₃₂H₅₈N₂O₇S
Purity
≥98% by NMR
Contaminants
DNase, RNase, and Protease: none detected
Solubility
H₂O (1.0 M)
Storage
+15°C to +30°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity
Harmful
Merck USA index
14, 2044
References
Chen, Y., et al. 1992. Biochemistry 31, 2415. Ofri, D., et al. 1992. J. Neurochem. 58, 628. Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823. Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA77, 4623. Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry31, 576. Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA77, 6368. Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA77, 4623.
