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SCC438 Calu-3 Human Lung Adenocarcinoma Cell Line

The characteristics of Calu3 cell line allow for a basic in vitro method of developing new therapeutics in an epithelial respiratory model.

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SCC438
≥1X10⁶ cells/vial  
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      Replacement Information
      Description
      Catalogue NumberSCC438
      DescriptionCalu-3 Human Lung Adenocarcinoma Cell Line
      Alternate Names
      • calu 3
      • calu3
      Background InformationLung cancer is the most common culprit of cancer-related deaths in the world.1 Even with advances in technology as well as treatment, it remains incredibly prevalent. Adenocarcinoma, which begins in the mucus producing cells of the body, is the most common sub-categorization of primary lung cancer. It accounts for about 40% of all cases of lung cancer.2 Adenocarcinoma is highly aggressive and is usually diagnosed at more advanced stages, resulting in low survival rates.
      Adenocarcinoma presents a variety of challenges due to its resistance to common treatments such as radiotherapy and chemotherapy. Combining multiple forms of therapy helps to overcome these roadblocks. The Calu-3 cell line can assist in finding potential drug therapies and has shown to be useful in mimicking in vivo conditions.3 This similarity has allowed for many pharmaceutical applications such as drug transport, studying aerosol deposition, controlled release studies, and identification of potential drug-drug interactions.4 The characteristics of Calu3 cell line allow for a basic in vitro method of developing new therapeutics in an epithelial respiratory model.

      Source
      The Calu-3 cell line was established by isolating cells located in the pleural effusion of a 25-year-old Caucasian man with lung adenocarcinoma.5

      References
      1. Semin Ultrasound CT MR 2019, 40(3): 255-264.
      2. Cell Death Dis 2018, 9(2): 117.
      3. J Control Release 2003, 87(1-3): 131-138.
      4. Expert Opin Drug Deliv 2013, 10(9): 1287-1302.
      5. J Natl Cancer Inst 1977, 59(1): 221-226.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationThe characteristics of Calu3 cell line allow for a basic in vitro method of developing new therapeutics in an epithelial respiratory model.
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      • Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      SCC438 04065267115528