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212385 Carbachol - CAS 51-83-2 - Calbiochem

212385
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Empirical FormulaCAS #
C₆H₁₅ClN₂O₂ 51-83-2

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212385-100MG
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      Description
      OverviewAn unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Carbachol is totally resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
      Catalogue Number212385
      Brand Family Calbiochem®
      SynonymsCarbamoylcholine Chloride
      References
      ReferencesJence, M., et al. 1995. J. Neurochem. 64, 1605.
      Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
      Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem. 267, 5847.
      Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
      Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther. 239, 574.
      Product Information
      CAS number51-83-2
      ATP CompetitiveN
      FormWhite fine crystalline solid
      Hill FormulaC₆H₁₅ClN₂O₂
      Chemical formulaC₆H₁₅ClN₂O₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAgonist for nicotinic and muscarinic acetylcholine receptors
      Purity≥99% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGA0875000
      Safety Information
      R PhraseR: 26/27/28-36/37/38

      Very toxic by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Carbachol - CAS 51-83-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Carbachol - CAS 51-83-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      212385

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jence, M., et al. 1995. J. Neurochem. 64, 1605.
      Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
      Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem. 267, 5847.
      Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
      Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther. 239, 574.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      SynonymsCarbamoylcholine Chloride
      DescriptionAn unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca2+ and InsP3 and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
      FormWhite fine crystalline solid
      CAS number51-83-2
      RTECSGA0875000
      Chemical formulaC₆H₁₅ClN₂O₂
      Structure formulaStructure formula
      Purity≥99% by titration
      SolubilityH₂O (100 mg/ml), Ethanol (20 mg/ml), and Methanol(100 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Highly Toxic
      Merck USA index14, 1779
      ReferencesJence, M., et al. 1995. J. Neurochem. 64, 1605.
      Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
      Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem. 267, 5847.
      Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
      Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther. 239, 574.