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218860 Casein Kinase II Inhibitor VIII - Calbiochem

218860
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₈H₁₄N₂O₄S

Prix & Disponibilité

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218860-10MG
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      Description
      OverviewA cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
      Catalogue Number218860
      Brand Family Calbiochem®
      Synonyms4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII
      References
      ReferencesHou, Z., et al. 2012. J. Med. Chem. 55, 2899.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₈H₁₄N₂O₄S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCK2
      Primary Target IC<sub>50</sub>32 and 46 nM for CK2&alpha
      Secondary targetDYRK1B, Flt-3
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Casein Kinase II Inhibitor VIII - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Casein Kinase II Inhibitor VIII - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      218860

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hou, Z., et al. 2012. J. Med. Chem. 55, 2899.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-June-2013 JSW
      Synonyms4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII
      DescriptionA cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHou, Z., et al. 2012. J. Med. Chem. 55, 2899.