235423 Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem

235423
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      Voir les Prix & la Disponibilité

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₉₄H₁₅₈N₂₀O₂₇

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      235423-1MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Ampoule plast. 1 mg
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          Description
          OverviewA cell-permeable inhibitor of caspase-3, as well as caspase-6, caspase-7, caspase-8, and caspase-10. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (Ki < 1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide. A 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235427) in DMSO is also available.
          Catalogue Number235423
          Brand Family Calbiochem®
          SynonymsCPP32/Apopain Inhibitor, Cell-permeable, Cell-permeable, DEVD-CHO
          References
          ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
          Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Tewari, M., et al. 1995. Cell 81, 801.
          Lazebnik, Y.A., et al. 1994. Nature 371, 346.
          Product Information
          ATP CompetitiveN
          FormLyophilized solid
          Hill FormulaC₉₄H₁₅₈N₂₀O₂₇
          Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
          ReversibleY
          Sold on the basis of peptide contentY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcaspase-3
          Primary Target IC<sub>50</sub>200 pM for inhibiting PARP cleavage in cultured human osteosarcoma cell extracts
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide ContentY
          Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          235423

          Références bibliographiques

          Aperçu de la référence bibliographique
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
          Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Tewari, M., et al. 1995. Cell 81, 801.
          Lazebnik, Y.A., et al. 1994. Nature 371, 346.

          Brochure

          Titre
          Caspases and other Apoptosis Related Tools Brochure

          Citations

          Titre
        • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.
        • Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-February-2014 JSW
          SynonymsCPP32/Apopain Inhibitor, Cell-permeable, Cell-permeable, DEVD-CHO
          DescriptionA cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent and reversible inhibitor of caspase-3 (Ki <1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 0.2 nM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
          FormLyophilized solid
          Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
          Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
          Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Tewari, M., et al. 1995. Cell 81, 801.
          Lazebnik, Y.A., et al. 1994. Nature 371, 346.
          Citation
        • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.