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264158 Caspase Modulator II, 1541B - Calbiochem

264158
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₃H₁₅N₃O₄

Prix & Disponibilité

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264158-10MG
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      10 mg
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      Description
      OverviewA cell-permeable, of 8-Hydroxy analog 1541 (Cat. No. 529662) that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective in cell death induction as simultaneous activations of caspase-3/-6 among cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.
      Catalogue Number264158
      Brand Family Calbiochem®
      SynonymsProcaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI
      References
      ReferencesWolan, D.W., et al. 2009. Science 326, 853.
      Product Information
      FormPale yellow solid
      Hill FormulaC₂₃H₁₅N₃O₄
      Chemical formulaC₂₃H₁₅N₃O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase Modulator II, 1541B - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Caspase Modulator II, 1541B - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      264158

      Références bibliographiques

      Aperçu de la référence bibliographique
      Wolan, D.W., et al. 2009. Science 326, 853.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-June-2011 RFH
      SynonymsProcaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI
      DescriptionA cell-permeable, of 8-Hydroxy 1541 (Cat. No. 529662) analog that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective as simultaneous activations of caspase-3/-6 in cell death induction of the cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₁₅N₃O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (1.8 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWolan, D.W., et al. 2009. Science 326, 853.