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218775 Castanospermine, Castanospermum australe - CAS 79831-76-8 - Calbiochem

Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine

Primary Target: β-glucosidases
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218775
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
79831-76-8C₈H₁₅NO₄

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218775-1MG
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      Description
      OverviewPlant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu3Man7-9(GlcNAc)2. Reduces bFGF induced angiogenesis in mice. Inhibits endothelial cell migration and invasion of basement membrane. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.
      Catalogue Number218775
      Brand Family Calbiochem®
      Synonyms(1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine
      References
      ReferencesAhmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.
      Pili, R., et al. 1995. Cancer Res. 55, 2920.
      Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 8120.
      Pan, Y.T., et al. 1983. Biochemistry 22, 3975.
      Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.
      Product Information
      CAS number79831-76-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₅NO₄
      Chemical formulaC₈H₁₅NO₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetβ-glucosidases
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      218775-1MG 04055977218732

      Documentation

      Castanospermine, Castanospermum australe - CAS 79831-76-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Castanospermine, Castanospermum australe - CAS 79831-76-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      218775

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ahmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.
      Pili, R., et al. 1995. Cancer Res. 55, 2920.
      Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 8120.
      Pan, Y.T., et al. 1983. Biochemistry 22, 3975.
      Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.

      Citations

      Titre
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-August-2010 JSW
      Synonyms(1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine
      DescriptionPlant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu3Man7-9 (GlcNAc)2. Inhibits endothelial cell angiogenesis and tumor growth. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number79831-76-8
      Chemical formulaC₈H₁₅NO₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 1896
      ReferencesAhmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.
      Pili, R., et al. 1995. Cancer Res. 55, 2920.
      Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 8120.
      Pan, Y.T., et al. 1983. Biochemistry 22, 3975.
      Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.
      Citation
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
      		•