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219415 Cathepsin Inhibitor I - Calbiochem

219415
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₆H₂₅N₃O₆

Prix & Disponibilité

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219415-1MG
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      Ampoule plast. 1 mg
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      Description
      OverviewCell-permeable cysteine protease inhibitor. Inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1 sec-1), and papain (k2/Ki = 2.4 x 103 M-1 sec-1).
      Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).
      Catalogue Number219415
      Brand Family Calbiochem®
      SynonymsZ-FG-NHO-Bz, CATI -1
      References
      ReferencesZhu, D. and Uckun, F.M. 2000. Clin. Cancer Res. 6, 2064.
      Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
      Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₂₅N₃O₆
      Chemical formulaC₂₆H₂₅N₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin B
      Primary Target K<sub>i</sub>k₂/Ki = 8.9 x 10³ M⁻¹sec⁻¹ for cathepsin B
      Purity>90% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Phe-Gly-NHO-Bz
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cathepsin Inhibitor I - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Cathepsin Inhibitor I - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      219415

      Références bibliographiques

      Aperçu de la référence bibliographique
      Zhu, D. and Uckun, F.M. 2000. Clin. Cancer Res. 6, 2064.
      Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
      Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

      Brochure

      Titre
      Cathepsins and Related Products Technical Bulletin
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-July-2011 JSW
      SynonymsZ-FG-NHO-Bz, CATI -1
      DescriptionCysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1sec-1), and papain (k2/Ki = 2.4 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).
      FormWhite solid
      Chemical formulaC₂₆H₂₅N₃O₆
      Peptide SequenceZ-Phe-Gly-NHO-Bz
      Structure formulaStructure formula
      Purity>90% by HPLC
      SolubilityAcetonitrile, DMSO, or Ethanol
      Storage +15°C to +30°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhu, D. and Uckun, F.M. 2000. Clin. Cancer Res. 6, 2064.
      Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
      Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.