217708 Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem

217708
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      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₂₂H₂₁N₃O₃S 71203-35-5

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      217708-25MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
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          Flacon en verre 25 mg
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          Description
          OverviewA cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (> 95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM.
          Catalogue Number217708
          Brand Family Calbiochem®
          SynonymsCID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II
          References
          ReferencesHong, L., et al. 2012. J. Biol. Chem. in press.
          Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)
          Product Information
          CAS number71203-35-5
          FormYellow-white solid
          Hill FormulaC₂₂H₂₁N₃O₃S
          Chemical formulaC₂₂H₂₁N₃O₃S
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationCdc42/Rac1 GTPase Inhibitor, ML141, CAS 71203-35-5, is a cell-permeable, allosteric, potent, selective, reversible, non-competitive inhibitor of Cdc42 GTPases.
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          217708

          Références bibliographiques

          Aperçu de la référence bibliographique
          Hong, L., et al. 2012. J. Biol. Chem. in press.
          Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-February-2013 JSW
          SynonymsCID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II
          DescriptionA cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (> 95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM.
          FormYellow-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number71203-35-5
          Chemical formulaC₂₂H₂₁N₃O₃S
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHong, L., et al. 2012. J. Biol. Chem. in press.
          Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)