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204896 Complement C8, Human

204896
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Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
204896-250UG
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      Ampoule plast. 250 μg
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      Description
      OverviewNative, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64 kDa (α), 64 kDa (β), and 22 kDa (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8 resulting in formation of the C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
      Catalogue Number204896
      Brand Family Calbiochem®
      References
      ReferencesSteckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
      Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.
      Product Information
      CAS number80295-58-5
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥85% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥150,000 C₈H₅0 units/mg
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsIgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Complement C8, Human FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Complement C8, Human Certificats d'analyse

      TitreNuméro de lot
      204896

      Références bibliographiques

      Aperçu de la référence bibliographique
      Steckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
      Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-August-2009 RFH
      DescriptionNative, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64,000 (α), 64,000 (β), and 22,000 (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8, resulting in formation of C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number80295-58-5
      Purity≥85% by SDS-PAGE
      ContaminantsIgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts
      Specific activity≥150,000 C₈H₅0 units/mg
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesSteckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
      Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.