Millipore Sigma Vibrant Logo

204863 Complement iC3b, Human

Complement iC3b, Human, is a native form that is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein.

Complement iC3b, Human : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
View Products on Sigmaaldrich.com
204863
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
204863-250UG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Ampoule plast. 250 μg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewNative, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
      Catalogue Number204863
      Brand Family Calbiochem®
      References
      ReferencesRosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99.
      Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.
      Product Information
      FormLiquid
      FormulationIn PBS, pH 7.2.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsIgG, IgA, IgM, C5, Factor H, or Factor I: ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      204863-250UG 04055977219647

      Documentation

      Complement iC3b, Human FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Complement iC3b, Human Certificats d'analyse

      TitreNuméro de lot
      204863

      Références bibliographiques

      Aperçu de la référence bibliographique
      Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99.
      Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-May-2008 RFH
      DescriptionNative, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α' polypeptides of M.W. 43,000 and M.W. 63,000 are disulfide bonded to the intact C3 b-chain (M.W. 75,000). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥90% by SDS-PAGE
      ContaminantsIgG, IgA, IgM, C5, Factor H, or Factor I: ≤trace amounts
      PreservativeNone
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesRosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99.
      Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.