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310500 D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

310500
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CAS #Empirical Formula
119567-63-4C₂₀H₄₁NO₂

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310500-5MG
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      Description
      OverviewA cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
      Catalogue Number310500
      Brand Family Calbiochem®
      SynonymsDMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
      References
      ReferencesCuvillier, O., et al. 1996. Nature 381, 800.
      Ohta, H., et al. 1995. Cancer Res. 55, 691.
      Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
      Hanada, K., et al. 1991. Biochemistry 30, 11682.
      Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.
      Product Information
      CAS number119567-63-4
      ATP CompetitiveN
      FormWaxy solid/Clear oil
      Hill FormulaC₂₀H₄₁NO₂
      Chemical formulaC₂₀H₄₁NO₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>12 µM against PKC
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      310500

      Références bibliographiques

      Aperçu de la référence bibliographique
      Cuvillier, O., et al. 1996. Nature 381, 800.
      Ohta, H., et al. 1995. Cancer Res. 55, 691.
      Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
      Hanada, K., et al. 1991. Biochemistry 30, 11682.
      Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.

      Brochure

      Titre
      Bioactive Lipids Technical Bulletin
      Caspases and other Apoptosis Related Tools Brochure
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsDMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
      DescriptionA cell-permeable and reversible inhibitor of protein kinase C (IC50 = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.
      FormWaxy solid/Clear oil
      CAS number119567-63-4
      Chemical formulaC₂₀H₄₁NO₂
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (5 mg/ml), Ethanol, or Methanol
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Toxicity Irritant
      ReferencesCuvillier, O., et al. 1996. Nature 381, 800.
      Ohta, H., et al. 1995. Cancer Res. 55, 691.
      Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
      Hanada, K., et al. 1991. Biochemistry 30, 11682.
      Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.