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317642 Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem

The Dipeptidylpeptidase IV Inhibitor IV, K579, also referenced under CAS 440100-64-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV

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317642
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Tableau de caractéristiques principal

CAS #Empirical Formula
440100-64-1C₁₇H₂₄N₆O

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317642-5MG
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      Description
      OverviewA cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
      Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
      Catalogue Number317642
      Brand Family Calbiochem®
      Synonyms(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV
      References
      ReferencesTakasaki, K., et al. 2004. Eur. J. Pharmacol. 505, 237.
      Takasaki, K., et al. 2004. Eur. J. Pharmacol. 486, 335.
      Takasaki, K., et al. 2004. J. Pharmacol. Sci. 95, 291.
      Product Information
      CAS number440100-64-1
      FormOff-white to light brown solid
      Hill FormulaC₁₇H₂₄N₆O
      Chemical formulaC₁₇H₂₄N₆O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      317642-5MG 04055977216271

      Documentation

      Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      317642

      Références bibliographiques

      Aperçu de la référence bibliographique
      Takasaki, K., et al. 2004. Eur. J. Pharmacol. 505, 237.
      Takasaki, K., et al. 2004. Eur. J. Pharmacol. 486, 335.
      Takasaki, K., et al. 2004. J. Pharmacol. Sci. 95, 291.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-June-2023 JSW
      Synonyms(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV
      DescriptionA cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
      FormOff-white to light brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number440100-64-1
      Chemical formulaC₁₇H₂₄N₆O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (32 mg/ml), Ethanol (6.5 mg/ml), or 1 eq HCl (16 mg/ml)

      Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesTakasaki, K., et al. 2004. Eur. J. Pharmacol. 505, 237.
      Takasaki, K., et al. 2004. Eur. J. Pharmacol. 486, 335.
      Takasaki, K., et al. 2004. J. Pharmacol. Sci. 95, 291.