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317700 Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem

317700
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₀H₂₂N₄ • HCl

Prix & Disponibilité

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317700-10MG
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      Description
      OverviewA 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
      Catalogue Number317700
      Brand Family Calbiochem®
      Synonyms(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
      References
      ReferencesPelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.
      Product Information
      FormYellow powder
      FormulationSupplied as a hydrochloride salt.
      Hill FormulaC₂₀H₂₂N₄ • HCl
      Chemical formulaC₂₀H₂₂N₄ • HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDkk-1 Inhibitor, WAY-262611, HCl, CAS 1123231-07-1, counteracts the antagonizing effect of Dkk-1 against Wnt-3a/LRP5 interaction. Prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      317700

      Références bibliographiques

      Aperçu de la référence bibliographique
      Pelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2016 JSW
      Synonyms(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
      DescriptionA 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
      FormYellow powder
      FormulationSupplied as a hydrochloride salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₂N₄ • HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.