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328006 ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

328006
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CAS #Empirical Formula
1049738-54-6C₁₄H₁₆N₂O₃S • HCl

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328006-5MG
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      Ampoule plast. 5 mg
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      Description
      OverviewA cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
      Catalogue Number328006
      Brand Family Calbiochem®
      Synonyms3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
      References
      ReferencesHancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.
      Product Information
      CAS number1049738-54-6
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₁₄H₁₆N₂O₃S • HCl
      Chemical formulaC₁₄H₁₆N₂O₃S • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetERK
      Primary Target IC<sub>50</sub>≤ 25 µM for anti-proliferative properties in HeLa, A549, and SUM-159 tumor cells; KD of ~5 µM for ERK2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ERK Inhibitor - CAS 1049738-54-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      ERK Inhibitor - CAS 1049738-54-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      328006

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      Synonyms3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
      DescriptionA cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1049738-54-6
      Chemical formulaC₁₄H₁₆N₂O₃S • HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.