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324483 Ebselen - CAS 60940-34-3 - Calbiochem

324483
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CAS #Empirical Formula
60940-34-3C₁₃H₉NOSe

Prix & Disponibilité

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324483-5MG
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      Description
      OverviewA cell-permeable, non-selective inhibitor of COX-1 and COX-2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent active against acute focal ischemic injury. Inhibits LPS-induced NF-κB nuclear translocation and LPS-induced phosphorylation of JNK.
      Catalogue Number324483
      Brand Family Calbiochem®
      Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
      References
      ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
      Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
      Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
      Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
      Wang, J.F., et al. 1992. Hepatology 5, 112.
      Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
      Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
      Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.
      Product Information
      CAS number60940-34-3
      ATP CompetitiveN
      FormLyophilized solid
      Hill FormulaC₁₃H₉NOSe
      Chemical formulaC₁₃H₉NOSe
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1, COX-2
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ebselen - CAS 60940-34-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Ebselen - CAS 60940-34-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324483

      Références bibliographiques

      Aperçu de la référence bibliographique
      Shimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
      Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
      Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
      Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
      Wang, J.F., et al. 1992. Hepatology 5, 112.
      Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
      Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
      Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.

      Brochure

      Titre
      Alzheimer's Disease Brochure & Technical Guide
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2008 RFH
      Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
      DescriptionNon-selective, cell-permeable, inhibitor of the cyclooxygenase activity of prostaglandin H synthase 1 and 2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent against acute focal ischemic injury.
      FormLyophilized solid
      CAS number60940-34-3
      Chemical formulaC₁₃H₉NOSe
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (5 mg/ml) or Ethanol
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
      Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
      Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
      Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
      Wang, J.F., et al. 1992. Hepatology 5, 112.
      Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
      Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
      Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.