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324683 Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

324683
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CAS #Empirical Formula
476-66-4C₁₄H₆O₈ · 2H₂O

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324683-500MG
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      Description
      OverviewA cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
      Catalogue Number324683
      Brand Family Calbiochem®
      Synonyms4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
      References
      ReferencesSelvi, B.R., et al. 2009, J. Biol. Chem. In press.
      Cozza, G., et al. 2006. J. Med. Chem. 49, 2363.
      Wang, B.H., et al. 1998. Planta Med. 64, 195.
      Constantinou, A., et al. 1995. Nutr. Cancer 23, 121.
      Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.
      Product Information
      CAS number476-66-4
      ATP CompetitiveY
      FormSlightly Beige Powder
      Hill FormulaC₁₄H₆O₈ · 2H₂O
      Chemical formulaC₁₄H₆O₈ · 2H₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCDK2
      Primary Target IC<sub>50</sub>40 nM against CK2; 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, against DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDJ2620000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324683

      Références bibliographiques

      Aperçu de la référence bibliographique
      Selvi, B.R., et al. 2009, J. Biol. Chem. In press.
      Cozza, G., et al. 2006. J. Med. Chem. 49, 2363.
      Wang, B.H., et al. 1998. Planta Med. 64, 195.
      Constantinou, A., et al. 1995. Nutr. Cancer 23, 121.
      Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-February-2019 JSW
      Synonyms4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
      DescriptionA cell-permeable, reversible, and potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
      FormSlightly Beige Powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number476-66-4
      RTECSDJ2620000
      Chemical formulaC₁₄H₆O₈ · 2H₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Solubility1 M NaOH (10 mg/ml) or Ethanol (10 mg/ml). For complete solubilization in ethanol, slight heating may be required.
      Storage +15°C to +30°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
      Toxicity Irritant
      Merck USA index14, 3547
      ReferencesSelvi, B.R., et al. 2009, J. Biol. Chem. In press.
      Cozza, G., et al. 2006. J. Med. Chem. 49, 2363.
      Wang, B.H., et al. 1998. Planta Med. 64, 195.
      Constantinou, A., et al. 1995. Nutr. Cancer 23, 121.
      Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

      Produits & Applications associés

      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Casein Kinase (CK) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Topoisomerase Related Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors