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344216 Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem

344216
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344216-5MG
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      Description
      OverviewA potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
      Catalogue Number344216
      Brand Family Calbiochem®
      SynonymsFPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂
      References
      ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
      Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
      Le, Y., et al. 1999. J. Immunol. 163, 6777.
      Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
      Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₁H₆₁N₉O₇S₂
      Chemical formulaC₄₁H₆₁N₉O₇S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFormyl Peptide Receptor-Like 1
      Primary Target IC<sub>50</sub>EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      344216

      Références bibliographiques

      Aperçu de la référence bibliographique
      Bae, Y.S., et al. 2004. J. Immunol. 173, 607.
      Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
      Le, Y., et al. 1999. J. Immunol. 163, 6777.
      Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
      Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2008 RFH
      SynonymsFPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂
      DescriptionA potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). More poteut than fmlp at inducing neutrophil chemotaxis, neutrophil complement receptor 3. Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM) and in U937 and HL60 cells. Has no effect inositide phosphate synthecs in a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Radioiodinatable at the tyrosine residue.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₁H₆₁N₉O₇S₂
      Peptide SequenceH-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
      Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
      Le, Y., et al. 1999. J. Immunol. 163, 6777.
      Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
      Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.