344282 Forskolin, Coleus forskohlii in DMSO - Calbiochem

344282
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      Voir les Prix & la Disponibilité

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₂₂H₃₄O₇

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      344282-5MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
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          Flacon en verre 5 mg
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          Description
          OverviewThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. The solid form of this compound (Cat. No. 344270) is also available.
          Catalogue Number344282
          Brand Family Calbiochem®
          References
          ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
          Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Galli, C., et al. 1995. J. Neurosci. 15, 1172.
          Li, X., et al. 1995. Am. J. Physiol. 269, C986.
          Lomo, J., et al. 1995. J. Immunol. 154, 1634.
          Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
          Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
          Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
          Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
          Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
          Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
          Product Information
          FormLiquid
          FormulationA 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.
          Hill FormulaC₂₂H₃₄O₇
          Chemical formulaC₂₂H₃₄O₇
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Forskolin, Coleus forskohlii in DMSO - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Forskolin, Coleus forskohlii in DMSO - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          344282

          Références bibliographiques

          Aperçu de la référence bibliographique
          D'Orazio, J.A., et al. 2006. Nature 443, 340.
          Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Galli, C., et al. 1995. J. Neurosci. 15, 1172.
          Li, X., et al. 1995. Am. J. Physiol. 269, C986.
          Lomo, J., et al. 1995. J. Immunol. 154, 1634.
          Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
          Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
          Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
          Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
          Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
          Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-February-2012 RFH
          DescriptionThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
          FormLiquid
          FormulationA 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₃₄O₇
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
          Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Galli, C., et al. 1995. J. Neurosci. 15, 1172.
          Li, X., et al. 1995. Am. J. Physiol. 269, C986.
          Lomo, J., et al. 1995. J. Immunol. 154, 1634.
          Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
          Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
          Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
          Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
          Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
          Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.