365251 Gö 6983 - CAS 133053-19-7 - Calbiochem

365251
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      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₂₆H₂₆N₄O₃ 133053-19-7

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      365251-500UG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
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          Contacter le Service Clients
          Contact Customer Service

          Ampoule plast. 500 μg
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          Description
          OverviewA potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
          Catalogue Number365251
          Brand Family Calbiochem®
          Synonyms2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
          References
          ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
          Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
          Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
          Product Information
          CAS number133053-19-7
          ATP CompetitiveY
          FormOrange red solid
          Hill FormulaC₂₆H₂₆N₄O₃
          Chemical formulaC₂₆H₂₆N₄O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationGö 6983, CAS 133053-19-7, is a potent, cell-permeable, reversible, and ATP-competitive inhibitor of several PKC isozymes (IC50 = 7 nM for PKCα & β; 6 nM for PKCγ; 10 nM for PKCδ; & 60 nM for PKCζ).
          Biological Information
          Primary TargetPKCα and PKCβ
          Primary Target IC<sub>50</sub>7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Gö 6983 - CAS 133053-19-7 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Gö 6983 - CAS 133053-19-7 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          365251

          Références bibliographiques

          Aperçu de la référence bibliographique
          Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
          Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
          Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.

          Citations

          Titre
        • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
        • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
        • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
        • Bai Luo, Stephen M. Prescott and Matthew K. Topham. (2003) Association of Diacylglycerol Kinase ζ with Protein Kinase C α: Spatial Regulation of Diacylglycerol Signaling. Journal of Cell Biology 160, 929-937.
        • Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-December-2015 JSW
          Synonyms2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
          DescriptionA potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
          FormOrange red solid
          CAS number133053-19-7
          Chemical formulaC₂₆H₂₆N₄O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
          Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
          Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
          Citation
        • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
        • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
        • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
        • Bai Luo, Stephen M. Prescott and Matthew K. Topham. (2003) Association of Diacylglycerol Kinase ζ with Protein Kinase C α: Spatial Regulation of Diacylglycerol Signaling. Journal of Cell Biology 160, 929-937.