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368050 Granzyme B Inhibitor I - Calbiochem

The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Granzyme B Inhibitor I - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Z-AAD-CMK

Primary Target: Granzyme B
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₁₉H₂₄ClN₃O₇
      Description
      OverviewA weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
      Catalogue Number368050
      Brand Family Calbiochem®
      SynonymsZ-AAD-CMK
      References
      ReferencesGong, B., et al. 1999. Cell Growth Different. 10, 491.
      Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
      Odake, S., et al. 1991. Biochemistry 30, 2217.
      Product Information
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₉H₂₄ClN₃O₇
      Chemical formulaC₁₉H₂₄ClN₃O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGranzyme B
      Primary Target IC<sub>50</sub>300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Ala-Ala-Asp-CH₂Cl
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      368050 0

      Documentation

      Granzyme B Inhibitor I - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Granzyme B Inhibitor I - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      368050

      Références bibliographiques

      Aperçu de la référence bibliographique
      Gong, B., et al. 1999. Cell Growth Different. 10, 491.
      Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
      Odake, S., et al. 1991. Biochemistry 30, 2217.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-July-2008 RFH
      SynonymsZ-AAD-CMK
      DescriptionA weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
      FormOff-white solid
      Chemical formulaC₁₉H₂₄ClN₃O₇
      Peptide SequenceZ-Ala-Ala-Asp-CH₂Cl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGong, B., et al. 1999. Cell Growth Different. 10, 491.
      Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
      Odake, S., et al. 1991. Biochemistry 30, 2217.

      Produits & Applications associés

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      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Granzyme Inhibitors