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400076 Hypericin - CAS 548-04-9 - Calbiochem

Polycyclic dione that has anti-retroviral activity.

Hypericin - CAS 548-04-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Casein Kinase II Inhibitor XI

Primary Target: PKC
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400076
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
548-04-9C₃₀H₁₆O₈

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400076-1MG
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      Description
      OverviewPolycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 μM). Also known to inhibit casein kinase II (IC50 = 6 nM), MAP kinase (IC50 = 4 nM), and the protein tyrosine activities of the insulin receptor (IC50 = 20-29 nM) and the epidermal growth factor receptor (IC50 = 35 nM).
      Catalogue Number400076
      Brand Family Calbiochem®
      SynonymsCasein Kinase II Inhibitor XI
      References
      ReferencesZhang, W., et al. 1997. Cancer Lett. 120, 31.
      Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
      Frew, T., et al. 1994. Anticancer Res. 14, 2425.
      Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
      Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.
      Product Information
      CAS number548-04-9
      ATP CompetitiveN
      FormBlack solid
      Hill FormulaC₃₀H₁₆O₈
      Chemical formulaC₃₀H₁₆O₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>3.3 µM, 6 nM, 4 nM, 20-29 nM , 35 nM, against protein kinase C, casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor, and the epidermal growth factor receptor, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      400076-1MG 04055977212303

      Documentation

      Hypericin - CAS 548-04-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Hypericin - CAS 548-04-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      400076

      Références bibliographiques

      Aperçu de la référence bibliographique
      Zhang, W., et al. 1997. Cancer Lett. 120, 31.
      Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
      Frew, T., et al. 1994. Anticancer Res. 14, 2425.
      Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
      Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-December-2015 JSW
      SynonymsCasein Kinase II Inhibitor XI
      DescriptionPolycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 µM). Also known to inhibit the protein tyrosine kinase activities of the insulin receptor (IC50 = 20-29 nM), the epidermal growth factor receptor (IC50 = 35 nM), casein kinase II (IC50 = 6 nM), and MAP kinase (IC50 = 4 nM). Useful probe for PKC due to its bright red fluorescence emission and photostability. Also see Pseudohypericin (Cat. No. 539590).
      FormBlack solid
      CAS number548-04-9
      Chemical formulaC₃₀H₁₆O₈
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml), Ethanol (1 mg/ml) or Methanol (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 4863
      ReferencesZhang, W., et al. 1997. Cancer Lett. 120, 31.
      Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
      Frew, T., et al. 1994. Anticancer Res. 14, 2425.
      Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
      Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.