420107 Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem

420107
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
Demander le prix
Disponibilité limitéeDisponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service
      Voir les Prix & la Disponibilité

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₃₆H₄₅BrN₄O₆ 102396-24-7

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      420107-50UG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Flacon en verre 50 μg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
          Demander le prix
          Description
          OverviewA cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca2+ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.
          Catalogue Number420107
          Brand Family Calbiochem®
          References
          ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
          Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
          Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
          Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
          Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
          Product Information
          CAS number102396-24-7
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₃₆H₄₅BrN₄O₆
          Chemical formulaC₃₆H₄₅BrN₄O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationJasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a cell-permeable F-actin probe. Induces actin polymerization and stabilization. Blocks activation of store-mediated Ca2+ entry into cells.
          Biological Information
          Primary TargetInducer of actin polymerization and stabilization in vitro
          Primary Target IC<sub>50</sub>Kd = 15 nM for actin binding
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          420107

          Références bibliographiques

          Aperçu de la référence bibliographique
          Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
          Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
          Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
          Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
          Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.

          Citations

          Titre
        • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
        • Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-July-2008 RFH
          DescriptionA cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number102396-24-7
          Chemical formulaC₃₆H₄₅BrN₄O₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
          Toxicity Harmful
          ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
          Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
          Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
          Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
          Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
          Citation
        • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.