Millipore Sigma Vibrant Logo

GF050 Leptin, mouse

Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice & appears to be involved in appetite control.

Leptin, mouse : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Key Applications: Cell Culture UniProt Number: P41159, P41160
View Products on Sigmaaldrich.com
GF050
1 mg  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Key ApplicationsSpeciesSourcePurity
      CULTMouse E.coliGreater than 95% by SDS-PAGE and HPLC analyses
      Description
      Catalogue NumberGF050
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionLeptin, mouse
      OverviewLeptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and appears to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body's fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Mouse leptin is a 16 kDa protein containing 147 amino acid residues.
      References
      Product Information
      HS Code3002 15 90
      PresentationLyophilized from 0.1% TFA, no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationLeptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice & appears to be involved in appetite control.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 95% by SDS-PAGE and HPLC analyses
      SourceE.coli
      Specific ActivityGF050 has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 μg leptin/gm of body weight for 14 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls.
      Entrez Gene SummaryThis gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P41159 # May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
      SIZE: 167 amino acids; 18641 Da
      SUBUNIT: Interacts with SIGLEC6.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P41159 # Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].
      SIMILARITY: SwissProt: P41159 ## Belongs to the leptin family.
      Stem Cell Type
      • Mesenchymal Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C for up to 12 months from date of receipt. After a quick spin, reconstitute the mouse leptin in sterile distilled water to a concentration of 1.0-5.0 mg/mL. After reconstitution maintain at -20°C in undiluted aliquots for up to six months.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      GF050 04053252509469

      Documentation

      Leptin, mouse FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Leptin, mouse Certificats d'analyse

      TitreNuméro de lot
      RECOMBINANT MOUSE LEPTIN 3123168
      RECOMBINANT MOUSE LEPTIN - 2332569 2332569
      RECOMBINANT MOUSE LEPTIN - 2011146 2011146
      RECOMBINANT MOUSE LEPTIN - 2109543 2109543
      RECOMBINANT MOUSE LEPTIN - 2208780 2208780
      RECOMBINANT MOUSE LEPTIN - 3180877 3180877
      RECOMBINANT MOUSE LEPTIN - 3244007 3244007
      RECOMBINANT MOUSE LEPTIN - 3277100 3277100
      RECOMBINANT MOUSE LEPTIN - 3322995 3322995
      RECOMBINANT MOUSE LEPTIN - 3328950 3328950
      Show more

      Produits & Applications associés

      Familles de produits

      Cytokines and Growth Factors

      EMD Millipore offers a comprehensive range of highly purified bioactive cytokines and growth factors for use in human, mouse, and rat cell culture, stem cell differentiation and ELISA studies.
      En savoir plus >>

      Catégories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors