444291 MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem

444291
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Empirical FormulaCAS #
C₁₉H₂₀N₂O₇S 1258003-93-8

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444291-5MG
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      Description
      OverviewA dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM , respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
      Catalogue Number444291
      Brand Family Calbiochem®
      Synonyms(S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid
      References
      ReferencesLi, W., et al. 2009. J. Med. Chem. 52, 1799.
      Product Information
      CAS number1258003-93-8
      FormOff-white solid
      Hill FormulaC₁₉H₂₀N₂O₇S
      Chemical formulaC₁₉H₂₀N₂O₇S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥94% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      444291

      Références bibliographiques

      Aperçu de la référence bibliographique
      Li, W., et al. 2009. J. Med. Chem. 52, 1799.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2011 RFH
      Synonyms(S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid
      DescriptionA dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1258003-93-8
      Chemical formulaC₁₉H₂₀N₂O₇S
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLi, W., et al. 2009. J. Med. Chem. 52, 1799.