444250 MMP Inhibitor I - Calbiochem

444250
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₃H₃₄N₆O₆

Prix & Disponibilité

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444250-10MG
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      Ampoule plast. 10 mg
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      Description
      OverviewA tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC50 = 1.0 µM), MMP-9 (IC50 = 30 µM) and MMP-3 (IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE® Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase.
      Catalogue Number444250
      Brand Family Calbiochem®
      SynonymsFN-439
      References
      ReferencesHagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
      Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₃H₃₄N₆O₆
      Chemical formulaC₂₃H₃₄N₆O₆
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationMMP Inhibitor I, CAS 124168-73-6, is an inhibitor of multiple MMPs (IC50 = 1.0, 1.0, 150, and 30 M for MMP-1, MMP-8, MMP-3, and MMP-9, respectively).
      Biological Information
      Primary TargetMMP-1, MMP-8
      Primary Target IC<sub>50</sub>1 µM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide Sequence4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MMP Inhibitor I - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      MMP Inhibitor I - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      444250

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
      Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

      Citations

      Titre
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
    • Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      SynonymsFN-439
      DescriptionA tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE® Protease (Cat. No. 53702) or human neutrophil elastase.
      FormWhite solid
      Chemical formulaC₂₃H₃₄N₆O₆
      Peptide Sequence4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
      Purity≥98% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesHagemamn, T., et al. 2004. Carcinogenesis 25, 1543.
      Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
      Citation
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.