444290 MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

444290
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      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₂₂H₂₈N₂O₆ 223472-31-9

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      444290-2MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
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          Ampoule plast. 2 mg
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          Description
          OverviewAn orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2, -3, -8, -9, -12, -13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
          Catalogue Number444290
          Brand Family Calbiochem®
          Synonyms(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
          References
          ReferencesOkamoto, Y., et al. 2007. Int. Heart J. 48, 369.
          Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
          Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
          Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
          Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
          Product Information
          CAS number223472-31-9
          FormOff-white solid
          Hill FormulaC₂₂H₂₈N₂O₆
          Chemical formulaC₂₂H₂₈N₂O₆
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MMP Inhibitor V - CAS 223472-31-9 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          MMP Inhibitor V - CAS 223472-31-9 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          444290

          Références bibliographiques

          Aperçu de la référence bibliographique
          Okamoto, Y., et al. 2007. Int. Heart J. 48, 369.
          Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
          Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
          Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
          Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2009 RFH
          Synonyms(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
          DescriptionAn orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2/3/8/9/12/13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number223472-31-9
          Chemical formulaC₂₂H₂₈N₂O₆
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (30 mg/ml) or Ethanol (15 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesOkamoto, Y., et al. 2007. Int. Heart J. 48, 369.
          Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
          Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
          Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
          Yamada, A., et al. 2000. Inflamm. Res. 49, 144.