445888 Metastin (45-54) - Calbiochem

445888
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₆₃H₈₃N₁₇O₁₄

Prix & Disponibilité

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445888-1MG
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      Ampoule plast. 1 mg
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      Description
      OverviewA decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM) compared to Metastin (Cat. No. 445885).
      Catalogue Number445888
      Brand Family Calbiochem®
      SynonymsKisspeptin-10, H-YNWNSFGLRF-NH₂, KiSS-1 (112-121)
      References
      ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₃H₈₃N₁₇O₁₄
      Chemical formulaC₆₃H₈₃N₁₇O₁₄
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationMetastin (45-54), CAS 374675-21-5, is a decapeptide that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).
      Biological Information
      Primary TargetAXOR12 and hOT7T175
      Primary Target K<sub>i</sub>42 pM for AXOR12 and hOT7T175
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Metastin (45-54) - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Metastin (45-54) - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      445888

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      SynonymsKisspeptin-10, H-YNWNSFGLRF-NH₂, KiSS-1 (112-121)
      DescriptionA decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₃H₈₃N₁₇O₁₄
      Peptide SequenceH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.