475944 Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem

475944
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₇H₉N₃O 5351-17-7

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      475944-1GM
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
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          Ampoule plast. 1 gm
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          Description
          OverviewA benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC50 = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60, human leukemia cells.
          Catalogue Number475944
          Brand Family Calbiochem®
          References
          ReferencesEngelmann, I., et al. 2000. Redox Report 5, 207.
          Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
          Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
          Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
          Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
          Product Information
          CAS number5351-17-7
          ATP CompetitiveN
          FormBeige solid
          Hill FormulaC₇H₉N₃O
          Chemical formulaC₇H₉N₃O
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetMyeloperoxidase
          Primary Target IC<sub>50</sub>300 nM against myeloperoxidase (MPO)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDG2580000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          475944

          Références bibliographiques

          Aperçu de la référence bibliographique
          Engelmann, I., et al. 2000. Redox Report 5, 207.
          Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
          Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
          Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
          Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          DescriptionA benzoic acid hydrazide analog that acts as a potent, specific, and irreversible inhibitor of myeloperoxidase. ABAH is a mechanism-based inhibitor that is oxidized to radical intermediates that, in turn, promote the irreversible inactivation of myeloperoxidase. Reported to inhibit hypochlorous acid (HOCl) production by purified myeloperoxidase (IC50 = 300 nM). Has also been shown to inhibit HOCl production up to 90% in zymosan and phorbol myristate acetate stimulated neutrophils (IC50 = 16 µM and 2.2 µM, respectively). Does not affect superoxide radical production or degranulation of neutrophils and does not inhibit catalase or glutathione peroxidase. Shown to inhibit myeloperoxidase-mediated apoptosis in >90% of ras-expressing fibroblasts and glutathione-depleted, src-transformed cells. Also shown to inhibit apoptosis in H2O2-treated HL-60 promyelocytic leukemia cells.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5351-17-7
          RTECSDG2580000
          Chemical formulaC₇H₉N₃O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) and dilute acids
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesEngelmann, I., et al. 2000. Redox Report 5, 207.
          Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
          Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
          Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
          Kettle, A.J., et al. 1995. Biochem. J. 308, 559.