34115 N-Ethylmaleimide - CAS 128-53-0 - Calbiochem

34115
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Empirical FormulaCAS #
C₆H₇NO₂ 128-53-0

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34115-5GM
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      Description
      OverviewSulfhydryl alkylating reagent that inhibits H+-ATPase and suppresses the short circuit current (IC50 = 22 µM) in pancreatic duct cells. Inactivates NADP-dependent isocitrate dehydrogenase. Also a potent inhibitor of both Mg2+ and Ca2+/Mg2+-stimulated DNA fragmentation in rat liver nuclei. Stimulates arachidonic acid release through activation of PLA2 in endothelial cells.
      Catalogue Number34115
      Brand Family Calbiochem®
      SynonymsNEM
      References
      ReferencesHuang, Y.C., et al. 1995. Arch. Biochem. Biophys. 316, 485.
      Neve, E.P.A., et al. 1995. Biochem. Pharmacol. 49, 57.
      Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
      Banger, K.K., et al. 1993. Biochem. J. 290, 199.
      Mattingly, J.R., Jr., et al. 1993. J. Biol. Chem. 268, 3925.
      Product Information
      CAS number128-53-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₆H₇NO₂
      Chemical formulaC₆H₇NO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetH+-ATPase
      Primary Target IC<sub>50</sub>22 µM in suppressing short circuit current
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUX9625000
      Safety Information
      R PhraseR: 21-28-34-43

      Harmful in contact with skin.
      Very toxic if swallowed.
      Causes burns.
      May cause sensitization by skin contact.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Corrosive
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      N-Ethylmaleimide - CAS 128-53-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      N-Ethylmaleimide - CAS 128-53-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      34115

      Références bibliographiques

      Aperçu de la référence bibliographique
      Huang, Y.C., et al. 1995. Arch. Biochem. Biophys. 316, 485.
      Neve, E.P.A., et al. 1995. Biochem. Pharmacol. 49, 57.
      Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
      Banger, K.K., et al. 1993. Biochem. J. 290, 199.
      Mattingly, J.R., Jr., et al. 1993. J. Biol. Chem. 268, 3925.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-February-2014 JSW
      SynonymsNEM
      DescriptionSulfhydryl alkylating reagent. Has been used for blocking sulfhydryl containing reagents which interfere with glucose oxidase assays. Inactivates NADP-dependent isocitrate dehydrogenase. Endonuclease inhibitor. Also a potent inhibitor of both Mg2+ and Ca2+/Mg2+-stimulated DNA fragmentation in rat liver nuclei.
      FormWhite solid
      CAS number128-53-0
      RTECSUX9625000
      Chemical formulaC₆H₇NO₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol (5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Corrosive
      Merck USA index14, 3822
      ReferencesHuang, Y.C., et al. 1995. Arch. Biochem. Biophys. 316, 485.
      Neve, E.P.A., et al. 1995. Biochem. Pharmacol. 49, 57.
      Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
      Banger, K.K., et al. 1993. Biochem. J. 290, 199.
      Mattingly, J.R., Jr., et al. 1993. J. Biol. Chem. 268, 3925.