480065 Necrostatin-1 - CAS 4311-88-0 - Calbiochem

480065
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      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₃H₁₃N₃OS 4311-88-0

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      480065-5MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
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          Ampoule plast. 5 mg
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          Description
          OverviewA cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). Also available as a 25 mM solution in DMSO (Cat. No. 505224).
          Catalogue Number480065
          Brand Family Calbiochem®
          SynonymsNecrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I, Nec1, RIP1 Inhibitor I, Necrosis Inhibitor II
          References
          ReferencesDegterev, A., et al. 2013. Nat. Chem. Biol. 9, 192.
          Degterev, A., et al. 2012. Cell Death Differ. 20, 366.
          Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320.
          Takahashi, N., et al. 2012. Cell Death Dis. 3, e437.
          Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313.
          Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
          Muller, A.J., et al. 2005. Nat. Med. 11, 312.
          Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.
          Product Information
          CAS number4311-88-0
          ATP CompetitiveY
          FormYellow crystalline solid
          Hill FormulaC₁₃H₁₃N₃OS
          Chemical formulaC₁₃H₁₃N₃OS
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetBlocker of necroptosis
          Primary Target IC<sub>50</sub>EC50 = 494 nM in blocking necrosis in FADD-deficient Jurkat cells treated with TNF-α
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Necrostatin-1 - CAS 4311-88-0 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Necrostatin-1 - CAS 4311-88-0 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          480065

          Références bibliographiques

          Aperçu de la référence bibliographique
          Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192.
          Degterev, A., et al. 2012. Cell Death Differ. 20, 366.
          Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320.
          Takahashi, N., et al. 2012. Cell Death Dis. 3, e437.
          Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313.
          Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
          Muller, A.J., et al. 2005. Nat. Med. 11, 312.
          Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-April-2008 JSW
          SynonymsNecrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I, Nec1, RIP1 Inhibitor I, Necrosis Inhibitor II
          DescriptionA cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066).
          FormYellow crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number4311-88-0
          Chemical formulaC₁₃H₁₃N₃OS
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDegterev, A., et al. 2013. Nat. Chem. Biol. 9, 192.
          Degterev, A., et al. 2012. Cell Death Differ. 20, 366.
          Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320.
          Takahashi, N., et al. 2012. Cell Death Dis. 3, e437.
          Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313.
          Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
          Muller, A.J., et al. 2005. Nat. Med. 11, 312.
          Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.