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676490 VEGFR2D1-7, Human, Recombinant, S. frugiperda

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Vascular Endothelial Growth Factor Receptor 2D1-7, Soluble KDR/Flk-1

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      Aperçu

      Replacement Information
      Description
      OverviewRecombinant, human VEGFR-2 consisting of all 7 immunoglobulin-like extracellular domains, but lacking the single transmembrane region and the intracellular split tyrosine kinase domain expressed in S. frugiperda insect cells. Binding of ligand to the full-length VEGFR-2 results in a high signaling activity and mitogenic activity in endothelial cells.
      Catalogue Number676490
      Brand Family Calbiochem®
      SynonymsVascular Endothelial Growth Factor Receptor 2D1-7, Soluble KDR/Flk-1
      References
      ReferencesRobinson, C.J., and Stringer, S.E. 2001 J. Cell Sci. 114, 853.
      Roeckl, W., et al. 1998. Exp. Cell Res. 241, 161.
      Product Information
      FormLyophilized
      FormulationLyophilized from 100 mM NaCl, 25 mM MES, pH 5.5.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityMeasured by the ability to inhibit VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells
      Purity≥90% by SDS-PAGE
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      676490 0

      Documentation

      VEGFR2D1-7, Human, Recombinant, S. frugiperda FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      VEGFR2D1-7, Human, Recombinant, S. frugiperda Certificats d'analyse

      TitreNuméro de lot
      676490

      Références bibliographiques

      Aperçu de la référence bibliographique
      Robinson, C.J., and Stringer, S.E. 2001 J. Cell Sci. 114, 853.
      Roeckl, W., et al. 1998. Exp. Cell Res. 241, 161.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      SynonymsVascular Endothelial Growth Factor Receptor 2D1-7, Soluble KDR/Flk-1
      DescriptionRecombinant, human VEGFR-2 consisting of all 7 immunoglobulin-like extracellular domains, but lacking the single transmembrane region and the intracellular split tyrosine kinase domain expressed in S. frugiperda insect cells. Contains all of the domains necessary for high affinity binding to VEGF. VEGFR-2 has a lower affinity for VEGF165 than VEGFR-1. However, VEGFR-2 has a higher signaling activity and is reported to mediate almost all observed endothelial cell responses to VEGF, including the increased microvascular permeability and endothelial cell proliferation. VEGFR-2 requires heparin for binding VEGF165.
      FormLyophilized
      FormulationLyophilized from 100 mM NaCl, 25 mM MES, pH 5.5.
      Purity≥90% by SDS-PAGE
      Biological activityMeasured by the ability to inhibit VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells
      SolubilityAqueous buffers (≥100 µg/ml) or H₂O (≥100 µg/ml)
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesRobinson, C.J., and Stringer, S.E. 2001 J. Cell Sci. 114, 853.
      Roeckl, W., et al. 1998. Exp. Cell Res. 241, 161.