688000 Sigma-AldrichY-27632 - CAS 331752-47-7 - Calbiochem
Y-27632, CAS 146986-50-7, is a cell-permeable, reversible, inhibitor of Rho kinases (Ki = 140 nM for p160ROCK). Enhances survival & cloning efficiency of ESC without affecting their pluripotency.
More>> Y-27632, CAS 146986-50-7, is a cell-permeable, reversible, inhibitor of Rho kinases (Ki = 140 nM for p160ROCK). Enhances survival & cloning efficiency of ESC without affecting their pluripotency. Less<<Y-27632 - CAS 331752-47-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 331752-47-7 | C₁₄H₂₁N₃O · 2HCl · H₂O |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 688000-100MG |
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Ampoule plast. | 100 mg |
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| 688000-10MG |
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Flacon en verre | 10 mg |
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| 688000-1MG |
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Ampoule plast. | 1 mg |
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| 688000-5MG |
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Flacon en verre | 5 mg |
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| Description | |
|---|---|
| Overview | A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. Pretreatment with Y-27632 reduces the risk of lung injury in rat models of sepsis. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and a 10 mM solution in DMSO (Cat. No. 688002) are also available. |
| Catalogue Number | 688000 |
| Brand Family | Calbiochem® |
| Synonyms | ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI |
| Product Information | |
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| CAS number | 331752-47-7 |
| ATP Competitive | Y |
| Declaration | Sold under license of PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation. |
| Form | White solid |
| Hill Formula | C₁₄H₂₁N₃O · 2HCl · H₂O |
| Chemical formula | C₁₄H₂₁N₃O · 2HCl · H₂O |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | p160 Rho-associated protein kinases (ROCK) |
| Primary Target K<sub>i</sub> | 140 nM for p160 Rho-associated protein kinases (ROCK) |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
| S Phrase | S: 36 Wear suitable protective clothing. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 688000-100MG | 04055977225402 |
| 688000-10MG | 04055977225396 |
| 688000-1MG | 07790788052362 |
| 688000-5MG | 07790788052379 |
Documentation
Y-27632 - CAS 331752-47-7 - Calbiochem FDS
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Y-27632 - CAS 331752-47-7 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 688000 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Cinel, I., et al. 2012. J. Thorac . Dis. 4, 30. Watanabe, K., et al. 2007. Nature Biotech. 25, 681. Chitaley, K., et al. 2001. Nat. Med. 7, 119. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Narumiya, S., et al. 2000. Methods Enzymol. 325, 273. Hirose, M., et al. 1998. J. Cell Biol. 141, 1625. Maekawa, M., et al. 1999. Science 285, 895. Uehata, M., et al. 1997. Nature 389, 990. |
Brochure
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| Bulk Product Guide |
Fiche technique
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| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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