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203701 bpV(HOpic) - Calbiochem

203701
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
K₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O

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203701-5MG
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      Description
      OverviewA potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).
      Catalogue Number203701
      Brand Family Calbiochem®
      SynonymsDipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV
      References
      ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
      Product Information
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaK₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O
      Chemical formulaK₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationbpV(HOpic), CAS 722494-26-0, is a potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also reported to potently inhibit PTEN (IC50 = 14 nM).
      Biological Information
      Primary TargetPTEN
      Primary Target IC<sub>50</sub>14 nM
      Purity≥70% by ⁵¹V-NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      bpV(HOpic) - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      bpV(HOpic) - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      203701

      Références bibliographiques

      Aperçu de la référence bibliographique
      Schmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

      Brochure

      Titre
      Protein Phosphatases Technical Bulletin
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2015 JSW
      SynonymsDipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV
      DescriptionA potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaK₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O
      Structure formulaStructure formula
      Purity≥70% by ⁵¹V-NMR
      SolubilityH₂O (4 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.