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324515 eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem

324515
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CAS #Empirical Formula
278603-08-0C₂₇H₄₅IN₂

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324515-5MG
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      Description
      OverviewA cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
      Catalogue Number324515
      Brand Family Calbiochem®
      Synonyms1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125
      References
      ReferencesArora, S., et al. 2004. Mol. Pharmacol. 66, 460.
      Arora, S., et al. 2003. Cancer Res. 63, 6894.
      Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.
      Product Information
      CAS number278603-08-0
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₇H₄₅IN₂
      Chemical formulaC₂₇H₄₅IN₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
      Primary Target IC<sub>50</sub>60 nM against the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324515

      Références bibliographiques

      Aperçu de la référence bibliographique
      Arora, S., et al. 2004. Mol. Pharmacol. 66, 460.
      Arora, S., et al. 2003. Cancer Res. 63, 6894.
      Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-June-2009 RFH
      Synonyms1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125
      DescriptionA cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number278603-08-0
      Chemical formulaC₂₇H₄₅IN₂
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityDMSO (20 mg/ml) or 70% Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesArora, S., et al. 2004. Mol. Pharmacol. 66, 460.
      Arora, S., et al. 2003. Cancer Res. 63, 6894.
      Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.