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324516 eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem

324516
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CAS #Empirical Formula
142557-61-7C₁₃H₁₅N₅O₃

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324516-10MG
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      Description
      OverviewA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
      Catalogue Number324516
      Brand Family Calbiochem®
      Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
      References
      ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
      Product Information
      CAS number142557-61-7
      FormOff-white powder
      Hill FormulaC₁₃H₁₅N₅O₃
      Chemical formulaC₁₃H₁₅N₅O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationeEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324516

      Références bibliographiques

      Aperçu de la référence bibliographique
      Chen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-July-2012 JSW
      Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
      DescriptionA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number142557-61-7
      Chemical formulaC₁₃H₁₅N₅O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (2.5 mg/ml; clear, colorless solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.