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324517 eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem

324517
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CAS #Empirical Formula
315706-13-9C₁₈H₁₂Cl₂N₄O₄S

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324517-10MG
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      Description
      OverviewA cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).
      Catalogue Number324517
      Brand Family Calbiochem®
      Synonyms2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
      References
      ReferencesMoerke, N. J., et al. 2007. Cell 128, 257.
      Product Information
      CAS number315706-13-9
      FormYellow solid
      Hill FormulaC₁₈H₁₂Cl₂N₄O₄S
      Chemical formulaC₁₈H₁₂Cl₂N₄O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationeIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation.
      Biological Information
      Purity≥98% by HPLC (sum of two isomers)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36-45

      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324517

      Références bibliographiques

      Aperçu de la référence bibliographique
      Moerke, N. J., et al. 2007. Cell 128, 257.

      Citations

      Titre
    • Hoeffer, C.A., et al. 2011. PNAS 8 3383.
    • Hoeffer et al. 2011. PNAS
    • Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-December-2013 JSW
      Synonyms2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
      DescriptionA cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number315706-13-9
      Chemical formulaC₁₈H₁₂Cl₂N₄O₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC (sum of two isomers)
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesMoerke, N. J., et al. 2007. Cell 128, 257.
      Citation
    • Hoeffer, C.A., et al. 2011. PNAS 8 3383.
    • Hoeffer et al. 2011. PNAS