With the increasing popularity and implementation of single-use technologies, the challenge of minimizing the potential of damage to these assemblies increases. This can lead to product delays, costly investigations and valuable product loss. With our extensive experience designing and developing single-use technologies, we have identified several safe handling tips and best practices for polyethylene film assemblies. All aspects of proper assembly handling, from the often overlooked warehouse and storage, through transport and end use are demonstrated below. Implementation of these practices can help prevent the expensive loss of product, time and frustration involved with a leak or non-conformance so more companies feel more confident in taking advantage of this trend.