スペルミジン

Finding the right critical raw material that matches your quality expectation can be challenging. Especially if you are advancing through clinical phases, changing regulatory requirements can raise several questions.

As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Spermidine has several applications beyond its chemical behavior as a base. The amino groups can interact with the phosphate groups of DNA and RNA and stabilize them. In addition, spermidine has a positive impact on transcription by RNA polymerases and can be found in several buffers. Within RNA bioprocessing, spermidine can be used for purification to bind and precipitate DNA. It may also be considered as adjuvant for mRNA vaccines.

The EMPROVE^® Expert quality grade provided with this product is tested for microbial and endotoxin levels and is RNase- and DNase-free. Stability studies according to ICH Q7 are running and stability conclusions will be available via EMPROVE^® Suite.

神経型一酸化窒素合成酵素（nNOS）を阻害します。DNAに結合し沈殿させ、DNA結合タンパク質の精製に使用できます。T₄ポリヌクレオチドキナーゼ活性を刺激します。

神経型一酸化窒素合成酵素（nNOS）を阻害します。DNAに結合し沈殿させます。T₄ポリヌクレオチドキナーゼ活性を刺激します。

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

滅菌が必要な場合は、オ-トクレ-ブではなく、濾過滅菌を行ってください。スペルミジンは経時的に脱アミノ化するので、溶液は凍結保存してください。溶液は用時調製してください。