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374000

Helenalin, A. chamissonis ssp. foliosa

Name: Helenalin, A. chamissonis <i>ssp. foliosa</i>
Brand: MM

別名:

Helenalin, A. chamissonis ssp. foliosa

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この商品について

実験式（ヒル表記法）:

C₁₅H₁₈O₄

CAS番号:

6754-13-8

分子量:

262.30

MDL number:

MFCD01674580

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated, protect from light

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特性

description

Merck USA index - 14, 4626

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated, protect from light

color

white to off-white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

O1[C@H]2[C@H]([C@@H]([C@]3([C@H]([C@@H](C2)C)C=CC3=O)C)O)C(=C)C1=O

InChI

1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3/t7-,9+,10-,12-,13+,15+/m1/s1

InChI key

ZVLOPMNVFLSSAA-XEPQRQSNSA-N

詳細

General description

A cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κB activation/nuclear translocation or IκB dissociation/degradation. An excellent research tool for studying NF-κB-mediated biological processes both in cultures in vitro and in animals in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Boulanger, D., et al. 2007. Vet. Microbiol.119, 330.
Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun.346, 314.
Huang, P.R., et al. 2005. Cancer Lett.227, 169.
Lyss, G., et al. 1998. J. Biol. Chem.273, 33508.
Lyss, G., et al. 1997. Biol. Chem.378, 951.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c