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676380

Valproic Acid sodium salt

Name: Valproic Acid sodium salt
Brand: MM

≥98% (HPLC), solid, HDAC1 inhibitor, Calbiochem^®

別名:

Valproic Acid, Sodium Salt, 2-Propylpentanoic Acid, Na

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この商品について

実験式（ヒル表記法）:

C₈H₁₅NaO₂

CAS番号:

1069-66-5

分子量:

166.19

UNSPSC Code:

12352106

NACRES:

NA.77

MDL number:

MFCD00078604

eCl@ss:

42020819

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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特性

製品名

Valproic Acid, Sodium Salt, A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1).

Quality Segment

100

description

Merck USA index - 14, 9913

assay

≥98% (HPLC)

form

solid

potency

400 μM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].[O-]C(=O)C(CCC)CCC

InChI

1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

InChI key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

詳細

General description

A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC₅₀ = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
HDAC1

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Gottlicher, M., et al. 2001. EMBO J.20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res.21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674.
Chen, G., et al. 1999. J. Neurochem.72, 1327.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361d

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c