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Merck

PHR1053

アルブテロール硫酸塩

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

Albuterol Sulfate, α-([t-Butylamino]methyl)-4-hydroxy-m-xylene-α,α′-diol, Salbutamol hemisulfate salt

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この商品について

実験式（ヒル表記法）:
C26H44N2O10S
分子量:
576.70
UNSPSC Code:
41116107
PubChem Substance ID:
329823083
EC Number:
256-916-8
NACRES:
NA.24

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SMILES string

[S](=O)(=O)(O)O.N(C(C)(C)C)CC(O)c2cc(c(cc2)O)CO.N(C(C)(C)C)CC(O)c1cc(c(cc1)O)CO

InChI key

BNPSSFBOAGDEEL-UHFFFAOYSA-N

InChI

1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. S0150000, traceable to USP 1012633

API family

albuterol, salbutamol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... ADRB2(154)

関連するカテゴリー

General description

Albuterol sulfate is a β2 adrenergic agonist and a bronchodilating agent, which is used in the treatment of asthma.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Albuterol sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by ultra-performance liquid chromatographic method with ultraviolet detection (UPLC-UV).
Albuterol sulfate may be used as a reference standard in determining the concentration of albuterol sulfate present in inhalers using reversed-phase high performance liquid chromatography (RP-HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7128 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Carc. 2 - Repr. 2 - Skin Sens. 1

保管分類

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

PHR1053-1G: + 59803-1G-BULK: + PHR1053-1G-BULK: + PHR1053-1G-PW: + 59803-1G:

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試験成績書（COA）

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以前この製品を購入いただいたことがある場合

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Comparison of conventional HPLC with UPLC method for determination of albuterol sulfate and it?s impurities in pharmaceutical formulation.
Dalvi PN, et al.
Orient. J. Chem., 24(2), 537-544 (2008)
Determination of albuterol sulfate and its related substances in albuterol sulfate inhalation solution, 0.5% by RP-HPLC
Erram.VS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(4), 864-874 (2006)
Supercritical and near-critical carbon dioxide assisted low-temperature bubble drying
Sievers.ER, et al.
Industrial & Engineering Chemistry Research, 39(12), 4831-4836 (2000)
B Padhukasahasram et al.
The pharmacogenomics journal, 14(4), 365-371 (2014-01-15)
Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA medication response using gene-based association tests. A linear mixed model approach was
Marc L Decramer et al.
International journal of chronic obstructive pulmonary disease, 8, 53-64 (2013-02-05)
Inhaled long-acting bronchodilators are the mainstay of pharmacotherapy for chronic obstructive pulmonary disease (COPD). Both the twice-daily long-acting β(2)-adrenoceptor agonists (LABAs) salmeterol and formoterol and the once-daily LABA indacaterol are indicated for use in COPD. This review examines current evidence
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