A5762
アデニン 9-β-D-アラビノフラノシド
≥99%
別名:
9-β-D-アラビノフラノシルアデニン, Ara-A, ビダラビン
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この商品について
実験式（ヒル表記法）:
C10H13N5O4
CAS番号:
分子量:
267.24
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
226-893-9
Beilstein/REAXYS Number:
624881
MDL number:
製品名
アデニン 9-β-D-アラビノフラノシド, ≥99%
InChI key
OIRDTQYFTABQOQ-UHTZMRCNSA-N
InChI
1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O
assay
≥99%
form
powder
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Ahcy(269378)
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関連するカテゴリー
General description
Adenine 9-β-D-arabinofuranoside (AraA) is a nucleoside analog. It is an antiviral drug and targets viral DNA polymerases and is majorly used for treating herpes simplex viral infection. It is a potent inhibitor of AMP-activated protein kinase (AMPK). It also inhibits cardiac type 5 adenylyl cyclase but does not improve pathology in cardiovascular diseases.
Biochem/physiol Actions
細胞透過性アデニル酸シクラーゼインヒビター。界面活性剤に分散させたラット脳標品におけるIC50 = 30 μM。DNAポリメラーゼ阻害による臨床的に重要な抗ウイルス薬(特に単純ヘルペス(HSV))。
膜透過性のアデニリルシクラ-ゼインヒビタ-です。界面活性剤分散処理を行ったラット脳サンプルにおけるIC50は30 μMです。
Application
Adenine 9-β-D-arabinofuranoside has been used for the inhibition of 5′ AMP-activated protein kinase (AMPK) in liver, muscle and cardiac cells H9c2.
Used to study the roles of AMP-activated protein kinase (AMPK) in cell signaling.
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK/mTOR signal pathway in H9c2 cells
Wei W, et al.
Molecular and Cellular Biochemistry, 389(1-2), 249-256 (2014)
The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation
Solinas G, et al.
Febs Letters, 577(3), 539-544 (2004)
AMPK involvement in endoplasmic reticulum stress and autophagy modulation after fatty liver graft preservation: a role for melatonin and trimetazidine cocktail
Zaouali MA, et al.
Journal of Pineal Research, 55(1), 65-78 (2013)
AMPK regulation of mouse oocyte meiotic resumption in vitro
Chen J, et al.
Developmental Biology, 291(2), 227-238 (2006)
Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs
Wada T, et al.
The Journal of Toxicological Sciences, 41(1), 115-122 (2016)
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